Astrocyte Ca²⁺ in the dorsal striatum suppresses neuronal activity to oppose cue-induced reinstatement of cocaine seeking.

ABSTRACT: Recent literature supports a prominent role for astrocytes in regulation of drug-seeking behaviors. The dorsal striatum, specifically, is known to play a role in reward processing with neuronal activity that can be influenced by astrocyte Ca²⁺. However, the manner in which Ca²⁺ in dorsal striatum astrocytes impacts neuronal signaling after exposure to self-administered cocaine remains unclear. We addressed this question following over-expression of the Ca²⁺ extrusion pump, hPMCA2w/b, in dorsal striatum astrocytes and the Ca²⁺ indicator, GCaMP6f, in dorsal striatum neurons of rats that were trained to self-administer cocaine. Following extinction of cocaine-seeking behavior, the rats over-expressing hMPCA2w/b showed a significant increase in cue-i

SUBMITTER: Tavakoli NS 

PROVIDER: S-EPMC11393831 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature