The FLARE Score and Circulating Neutrophils in Patients with Cancer and COVID-19 Disease.

ABSTRACT:

Purpose

Inflammation and neutrophils play a central role in both COVID-19 disease and cancer. We aimed to assess the impact of pre-existing tumor-related inflammation on COVID-19 outcomes in patients with cancer and to elucidate the role of circulating neutrophil subpopulations.

Methods

We conducted a multicenter retrospective analysis of 524 patients with cancer and SARS-CoV-2 infection, assessing the relationship between clinical outcomes and circulating inflammatory biomarkers collected before and during COVID-19 infection. Additionally, a single-center prospective cohort study provided data for an exploratory analysis, assessing the immunophenotype of circulating neutrophils and inflammatory cytokines. The primary endpoints were 30-day mortality and the severity of COVID

SUBMITTER: Segui E 

PROVIDER: S-EPMC11393969 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature