Embryonic Leucine Promotes Early Postnatal Growth via mTOR Signalling in Japanese Quails.

ABSTRACT: Nutritional cues during embryonic development can alter developmental trajectories and affect postnatal growth. However, the specific mechanisms by which nutrients influence avian growth remain largely unknown. Amino acids can directly interact with the nutrient-sensing pathways, such as the insulin-like growth factor 1 (IGF-1)/mechanistic target of rapamycin (mTOR) pathways, which are known to regulate growth. We examined the effects of embryonic leucine on gene expression and phenotypic growth in Japanese quails by injecting 2.5 mg leucine or saline (control) into Japanese quail eggs on the tenth day of incubation and incubating them under standard conditions. The treatment groups had similar hatching success and size at hatching. However, between 3 and 7 days post-hatching, quails treat

SUBMITTER: Ndunguru SF 

PROVIDER: S-EPMC11394045 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature