Inverse Correlation between pks-Carrying Escherichia coli Abundance in Colorectal Cancer Liver Metastases and the Number of Organs Involved in Recurrence.

ABSTRACT: Colibactin, a genotoxin produced by Escherichia coli strains harboring the polyketide synthetase (pks) gene cluster, causes DNA damage and somatic mutations. pks⁺E. coli is enriched in primary colorectal cancer (CRC) and is associated with clonal driver mutations, but its role in CRC liver metastasis is unclear. We assessed the association of pks⁺ E. coli in CRC liver metastasis tissues with systemic and local immune responses and the number of organs involved in recurrence using specimens and clinicopathological data from 239 patients with CRC liver metastasis who underwent metastasectomy. The levels of pks⁺E. coli in fresh-frozen specimens were quantified as "very low" (<50th percentile), "low" (50th to 75t

SUBMITTER: Shigematsu Y 

PROVIDER: S-EPMC11394077 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature