1,25-Dihydroxyvitamin D Enhances the Regenerative Function of Lgr5⁺ Intestinal Stem Cells In Vitro and In Vivo.

ABSTRACT: Inflammatory bowel disease (IBD) is a chronic inflammatory disorder in the intestines without a cure. Current therapies suppress inflammation to prevent further intestinal damage. However, healing already damaged intestinal epithelia is still an unmet medical need. Under physiological conditions, Lgr5⁺ intestinal stem cells (ISCs) in the intestinal crypts replenish the epithelia every 3-5 days. Therefore, understanding the regulation of Lgr5⁺ ISCs is essential. Previous data suggest vitamin D signaling is essential to maintain normal Lgr5⁺ ISC function in vivo. Our recent data indicate that to execute its functions in the intestines optimally, 1,25(OH)₂D requires high concentrations that, if present systemically, can cause hypercalcemia (i.e., bl

SUBMITTER: Shaikh NA 

PROVIDER: S-EPMC11394149 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature