Estimating cell-type-specific gene co-expression networks from bulk gene expression data with an application to Alzheimer's disease.

ABSTRACT: Inferring and characterizing gene co-expression networks has led to important insights on the molecular mechanisms of complex diseases. Most co-expression analyses to date have been performed on gene expression data collected from bulk tissues with different cell type compositions across samples. As a result, the co-expression estimates only offer an aggregated view of the underlying gene regulations and can be confounded by heterogeneity in cell type compositions, failing to reveal gene coordination that may be distinct across different cell types. In this paper, we introduce a flexible framework for estimating cell-type-specific gene co-expression networks from bulk sample data, without making specific assumptions on the distributions of gene expression profiles in different cell types.

SUBMITTER: Su C 

PROVIDER: S-EPMC11394578 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature