Maternal Plasma miRNAs as Early Biomarkers of Moderate-to-Late-Preterm Birth.

ABSTRACT: Globally, preterm birth (PTB) is a primary cause of mortality and morbidity in infants, with PTB rates increasing worldwide over the last two decades. Biomarkers for accurate early prediction of PTB before the clinical event do not currently exist. Given their roles in the development and progression of many disease states, there has been increasing interest in the utility of microRNAs (miRNAs) as early biomarkers for pregnancy-related disorders, including PTB. The present study was designed to examine potential differences in miRNA abundances in maternal plasma from mothers with infants born following a moderate to late (28-36 weeks' gestation, n = 54) spontaneous PTB (SPTB) compared to mothers with matched term infants (n = 54). Maternal plasma collected at 15 weeks' gestation were utili

SUBMITTER: Ramzan F 

PROVIDER: S-EPMC11394737 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature