Synergistic Toxicity of Pollutant and Ultraviolet Exposure from a Mitochondrial Perspective.

ABSTRACT: Ultraviolet (UV) exposure and atmospheric pollution are both independently implicated in skin diseases such as cancer and premature aging. UVA wavelengths, which penetrate in the deep layers of the skin dermis, exert their toxicity mainly through chromophore photosensitization reactions. Benzo[a]pyrene (BaP), the most abundant polycyclic aromatic hydrocarbon originating from the incomplete combustion of organic matter, could act as a chromophore and absorb UVA. We and other groups have previously shown that BaP and UVA synergize their toxicity in skin cells, which leads to important oxidation. Even if mitochondria alterations have been related to premature skin aging and other skin disorders, no studies have focused on the synergy between UV exposure and pollution on mitochondria. Our stud

SUBMITTER: Larnac E 

PROVIDER: S-EPMC11394743 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature