A method for subtype analysis with somatic mutations.

ABSTRACT:

Motivation

Cancer is a highly heterogeneous disease, and virtually all types of cancer have subtypes. Understanding the association between cancer subtypes and genetic variations is fundamental to the development of targeted therapies for patients. Somatic mutation plays important roles in tumor development and has emerged as a new type of genetic variations for studying the association with cancer subtypes. However, the low prevalence of individual mutations poses a tremendous challenge to the related statistical analysis.

Results

In this article, we propose an approach, subtype analysis with somatic mutations (SASOM), for the association analysis of cancer subtypes with somatic mutations. Our approach tests the association between a set of somatic mutations (from a genetic

SUBMITTER: Liu M 

PROVIDER: S-EPMC11394914 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature