The Unexplored Role of Mitochondria-Related Oxidative Stress in Diverticular Disease.

ABSTRACT: The pathophysiology of diverticular disease (DD) is not well outlined. Recent studies performed on the DD human ex vivo model have shown the presence of a predominant transmural oxidative imbalance whose origin remains unknown. Considering the central role of mitochondria in oxidative stress, the present study evaluates their involvement in the alterations of DD clinical phenotypes. Colonic surgical samples of patients with asymptomatic diverticulosis, complicated DD, and controls were analyzed. Electron microscopy, protein expression, and cytofluorimetric analyses were performed to assess the contribution of mitochondrial oxidative stress. Functional muscle activity was tested on cells in response to contractile and relaxant agents. To assess the possibility of reverting oxidative damages

SUBMITTER: Cappelletti M 

PROVIDER: S-EPMC11395029 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature