Large Extracellular Vesicles Derived from Natural Killer Cells Affect the Functions of Monocytes.

ABSTRACT: Communication between natural killer cells (NK cells) and monocytes/macrophages may play an important role in immunomodulation and regulation of inflammatory processes. The aim of this research was to investigate the impact of NK cell-derived large extracellular vesicles on monocyte function because this field is understudied. We studied how NK-cell derived large extracellular vesicles impact on THP-1 cells characteristics after coculturing: phenotype, functions were observed with flow cytometry. In this study, we demonstrated the ability of large extracellular vesicles produced by NK cells to integrate into the membranes of THP-1 cells and influence the viability, phenotype, and functional characteristics of the cells. The results obtained demonstrate the ability of large extracellular ve

SUBMITTER: Sokolov D 

PROVIDER: S-EPMC11395174 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature