Analytical Investigation of the Profile of Human Chorionic Gonadotropin in Highly Purified Human Menopausal Gonadotrophin Preparations.

ABSTRACT: Highly purified human menopausal gonadotropin (HP-hMG [Menopur^®, Ferring Pharmaceuticals, Saint-Prex, Switzerland]) contains a 1:1 ratio of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). This analysis aimed to assess gonadotropin (FSH, LH and hCG) abundance in HP-hMG and clarify the source of hCG by assessing the presence of sulfated glycans, which are diagnostic for pituitary hCG forms due to their distinct glycosylation patterns. Additionally, the purity of each sample, their specific components, and their oxidation levels were assessed. HP-hMG samples (three of Menopur^® and two of Menogon^® Ferring Pharmaceuticals, Saint-Prex, Switzerland) were included in the current analyses. Brevactid^® (urinary hCG; Ferring Pharmaceuticals,

SUBMITTER: Capolupo A 

PROVIDER: S-EPMC11395176 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature