KC-like chemokine as a biomarker of sepsis in dogs with pyometra.

ABSTRACT:

Background

Sepsis, defined as a dysregulated inflammatory response to infection inducing organ dysfunction, is a common cause of mortality in both humans and animals. Early detection and treatment is essential for survival, but accurate diagnosis is challenging due to the lack of specific biomarkers for sepsis. This study explored the potential of the keratinocyte-derived chemokine (KC)-like protein in dogs as a biomarker of sepsis in dogs with bacterial uterine infection (pyometra). The aim was to compare KC-like concentrations in dogs with pyometra with or without sepsis and to assess associations between KC-like and clinical variables, including days of hospitalization as an outcome.

Results

A mouse KC ELISA was validated and used to determine the concentrations of KC-lik

SUBMITTER: Hagman R 

PROVIDER: S-EPMC11395178 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature