A multifunctional targeted nano-delivery system with radiosensitization and immune activation in glioblastoma.

ABSTRACT: Glioblastoma (GBM), the most common primary brain malignancy in adults, is notoriously difficult to treat due to several factors: tendency to be radiation resistant, the presence of the blood brain barrier (BBB) which limits drug delivery and immune-privileged status which hampers effective immune responses. Traditionally, high-dose irradiation (8 Gy) is known to effectively enhance anti-tumor immune responses, but its application is limited by the risk of severe brain damage. Currently, conventional dose segmentation (2 Gy) is the standard radiotherapy method, which does not fully exploit the potential of high-dose irradiation for immune activation. The hypothesis of our study posits that instead of directly applying high doses of radiation, which is risky, a strategy could be developed t

SUBMITTER: Wen X 

PROVIDER: S-EPMC11395210 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature