Anti-CD44 Variant 10 Monoclonal Antibody Exerts Antitumor Activity in Mouse Xenograft Models of Oral Squamous Cell Carcinomas.

ABSTRACT: CD44 regulates cell adhesion, proliferation, survival, and stemness and has been considered a tumor therapy target. CD44 possesses the shortest CD44 standard (CD44s) and a variety of CD44 variant (CD44v) isoforms. Since the expression of CD44v is restricted in epithelial cells and carcinomas compared to CD44s, CD44v has been considered a promising target for monoclonal antibody (mAb) therapy. We previously developed an anti-CD44v10 mAb, C₄₄Mab-18 (IgM, kappa), to recognize the variant exon 10-encoded region. In the present study, a mouse IgG_2a version of C₄₄Mab-18 (C₄₄Mab-18-mG_2a) was generated to evaluate the antitumor activities against CD44-positive cells compared with the previously established anti-pan CD44 mAb, C₄₄Mab-

SUBMITTER: Ishikawa K 

PROVIDER: S-EPMC11395228 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature