Eco-Friendly Functionalization of Ynals with Thiols under Mild Conditions.

ABSTRACT: A new eco-friendly method for the synthesis of mono- and multifunctional organosulfur compounds, based on the process between ynals and thiols, catalyzed by bulky N-heterocyclic carbene (NHC), was designed and optimized. The proposed organocatalytic approach allows the straightforward formation of a broad range of thioesters and sulfenyl-substituted aldehydes in yields above 86%, in mild and metal-free conditions. In this study, thirty-six sulfur-based derivatives were obtained and characterized by spectroscopic methods.

SUBMITTER: Hanek K 

PROVIDER: S-EPMC11395323 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature