Study of Insulin Aggregation and Fibril Structure under Different Environmental Conditions.

ABSTRACT: Protein amyloid aggregation is linked with widespread and fatal neurodegenerative disorders as well as several amyloidoses. Insulin, a small polypeptide hormone, is associated with injection-site amyloidosis and is a popular model protein for in vitro studies of amyloid aggregation processes as well as in the search for potential anti-amyloid compounds. Despite hundreds of studies conducted with this specific protein, the procedures used have employed a vast array of different means of achieving fibril formation. These conditions include the use of different solution components, pH values, ionic strengths, and other additives. In turn, this variety of conditions results in the generation of fibrils with different structures, morphologies and stabilities, which severely limits the possibili

SUBMITTER: Ziaunys M 

PROVIDER: S-EPMC11395423 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature