Mesocorticolimbic and Cardiometabolic Diseases-Two Faces of the Same Coin?

ABSTRACT: The risk behaviors underlying the most prevalent chronic noncommunicable diseases (NCDs) encompass alcohol misuse, unhealthy diets, smoking and sedentary lifestyle behaviors. These are all linked to the altered function of the mesocorticolimbic (MCL) system. As the mesocorticolimbic circuit is central to the reward pathway and is involved in risk behaviors and mental disorders, we set out to test the hypothesis that these pathologies may be approached therapeutically as a group. To address these questions, the identification of novel targets by exploiting knowledge-based, network-based and disease similarity algorithms in two major Thomson Reuters databases (MetaBase™, a database of manually annotated protein interactions and biological pathways, and Integrity^SM, a unique knowle

SUBMITTER: Papp C 

PROVIDER: S-EPMC11395462 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature