Association Study of <i>CACNA1D</i>, <i>KCNJ11</i>, <i>KCNQ1</i>, and <i>CACNA1E</i> Single-Nucleotide Polymorphisms with Type 2 Diabetes Mellitus.

ABSTRACT: Type 2 diabetes mellitus (T2DM) is a complex chronic disease characterized by decreased insulin secretion and the development of insulin resistance. Previous genome-wide association studies demonstrated that single-nucleotide polymorphisms (SNPs) present in genes coding for ion channels involved in insulin secretion increase the risk of developing this disease. We determined the association of 16 SNPs found in CACNA1D, KCNQ1, KCNJ11, and CACNA1E genes and the increased probability of developing T2DM. In this work, we performed a case-control study in 301 Mexican adults, including 201 cases with diabetes and 100 controls without diabetes. Our findings indicate a moderate association between T2DM and the C allele, and the C/C genotype of rs312480 within CACNA1D

SUBMITTER: Diaz-Garcia JD 

PROVIDER: S-EPMC11395491 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature