A Spironolactone-Based Prototype of an Innovative Biomedical Patch for Wound Dressing Applications.

ABSTRACT: The electrospinning process is an effective technique for creating micro- and nanofibers from synthetic and natural polymers, with significant potential for biomedical applications and drug delivery systems due to their high drug-loading capacity, large surface area, and tunable release times. Poly(L-lactic acid) (PLLA) stands out for its excellent thermo-mechanical properties, biodegradability, and bioabsorbability. Electrospun PLLA nanofibrous structures have been extensively investigated as wound dressings, sutures, drug delivery carriers, and tissue engineering scaffolds. This study aims to create and characterize electrospun PLLA membranes loaded with spironolactone (SP), mimicking active compounds of Ganoderma lucidum (GL), to develop a biodegradable patch for topical wound-he

SUBMITTER: Aquino G 

PROVIDER: S-EPMC11395607 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature