Baseline gut microbiota diversity and composition and albendazole efficacy in hookworm-infected individuals.

ABSTRACT: Soil-transmitted helminth (STH) infections account for a significant global health burden, necessitating mass drug administration with benzimidazole-class anthelmintics, such as albendazole (ALB), for morbidity control. However, ALB efficacy shows substantial variability, presenting challenges for achieving consistent treatment outcomes. We have explored the potential impact of the baseline gut microbiota on ALB efficacy in hookworm-infected individuals through microbiota profiling and machine learning (ML) techniques. Our investigation included 89 stool samples collected from hookworm-infected individuals that were analyzed by microscopy and quantitative PCR (qPCR). Of these, 44 were negative by microscopy for STH infection using the Kato-Katz method and qPCR 21 days after treatment, whic

SUBMITTER: Gandasegui J 

PROVIDER: S-EPMC11395646 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature