Glucose intolerance as a consequence of hematopoietic stem cell dysfunction in offspring of obese mice.

ABSTRACT:

Objective

Maternal obesity is increasingly common and negatively impacts offspring health. Children of mothers with obesity are at higher risk of developing diseases linked to hematopoietic system abnormalities and metabolism such as type 2 diabetes. Interestingly, disease risks are often dependent on the offspring's sex, suggesting sex-specific reprogramming effect of maternal obesity on offspring hematopoietic stem and progenitor cell (HSPC) function. However, the impact of maternal obesity exposure on offspring HSPC function, and the capability of HSPC to regulate offspring metabolic health is largely understudied. This study aims to test the hypothesis that offspring of obese mice exhibit sex-differences in HSPC function that affect offspring's metabolic health.

Methods

SUBMITTER: Denizli M 

PROVIDER: S-EPMC11395717 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature