Oral administration of tea-derived exosome-like nanoparticles protects epithelial and immune barrier of intestine from psychological stress.

ABSTRACT: Psychological stress disrupts the integrity of the intestinal barrier and is strongly linked to emotional disorders, behavioral changes, and gastrointestinal dysfunction. However, there are limited treatment options available for repairing the damage to the intestinal barrier. As a natural plant-based health beverage, tea (Camellia sinensis) has been shown to have various potentially advantageous effects on the intestinal barrier and immune function. In this study, we extracted bioactive molecules from tea leaves, named exosome-like nanoparticles (ELNs), and then examined their potential protective properties for the intestinal barrier. Through in vitro experimentation, we investigated whether tea-derived ELNs (TELNs) could offer a protective effect against lipopolysaccharides-induc

SUBMITTER: Gong Q 

PROVIDER: S-EPMC11395767 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature