Phytochemical profiling and anticancer potential of gardenia latifolia extracts against arsenic trioxide induced liver fibrosis in rat model.

ABSTRACT:

Introduction

Arsenic trioxide (As₂O₃) is an environmental contaminant that may cause hepatic injuries. As₂O₃-induced liver injuries are detected as an underlying cause of hepatocellular carcinoma (HCC) around the globe. The present study aimed to investigate the potential of Gardenia latifolia (GL) extracts against oxidative stress and apoptotic activity in HCC-induced rats and to explore in silico molecular docking analysis of phytocompounds of G. latifolia.

Methods

The present study was designed to investigate the hepato-protective effect of ethanol and n-hexane extract of G. latifolia. Phytochemical analysis was performed using gas-chromatography-mass spectrometry (GC-MS), and the identified me

SUBMITTER: Mehboob Z 

PROVIDER: S-EPMC11395838 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature