Energy metabolism-related GLUD1 contributes to favorable clinical outcomes of IDH-mutant glioma.

ABSTRACT:

Background

Glioma is the most common brain tumor. IDH mutations occur frequently in glioma, indicating a more favorable prognosis. We aimed to explore energy metabolism-related genes in glioma to promote the research and treatment.

Methods

Datasets were obtained from TCGA and GEO databases. Candidate genes were screened by differential gene expression analysis, then functional enrichment analysis was conducted on the candidate genes. PPI was also carried out to help determine the target gene. GSEA and DO analysis were conducted in the different expression level groups of the target gene. Survival analysis and immune cell infiltrating analysis were performed as well.

Results

We screened 34 candidate genes and selected GLUD1 as the target gene. All candidate genes were

SUBMITTER: Deng R 

PROVIDER: S-EPMC11395857 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature