Microbiota-targeted interventions and clinical implications for maternal-offspring health: An umbrella review of systematic reviews and meta-analyses of randomised controlled trials.

ABSTRACT:

Background

Microbes in the human body are the determinants of life-long health and disease. Microbiome acquisition starts in utero and matures during early childhood through breastfeeding. However, maternal gut dysbiosis affects the maternal-offspring microbiome interplay. Lines of evidence on dysbiosis-targeted interventions and their effect on maternal-offspring health and gut microbiome are inconsistent and inconclusive. Therefore, this study summarised studies to identify the most common microbiota-targeted intervention during pregnancy and lactation and to comprehensively evaluate its effects on maternal and offspring health.

Methods

This umbrella review was conducted by systematically searching databases such as PubMed and the Web of Science from inception to 2 Septemb

SUBMITTER: Alemu BK 

PROVIDER: S-EPMC11395958 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature