Replacement of sedentary behavior with various physical activities and the risk of all-cause and cause-specific mortality.

ABSTRACT:

Background

Sedentary behavior (SB) has emerged as a significant health concern that deserves attention. This study aimed to examine the associations between prolonged sedentary behavior and the risk of all-cause and cause-specific mortality as well as to explore desirable alternatives to sitting in terms of physical activity (PA).

Methods

Two prospective cohort investigations were conducted using the UK Biobank and NHANES datasets, with a total of 490,659 and 33,534 participants, respectively. Cox proportional hazards regression models were used to estimate the associations between SB and the risk of all-cause and cause-specific mortality due to cancer, cardiovascular disease (CVD), respiratory diseases, and digestive diseases. In addition, we employed isotemporal substituti

SUBMITTER: Chang Q 

PROVIDER: S-EPMC11395964 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature