Respiratory Drive, Effort, and Lung-Distending Pressure during Transitioning from Controlled to Spontaneous Assisted Ventilation in Patients with ARDS: A Multicenter Prospective Cohort Study.

ABSTRACT: Objectives: To investigate the impact of patient characteristics and treatment factors on excessive respiratory drive, effort, and lung-distending pressure during transitioning from controlled to spontaneous assisted ventilation in patients with acute respiratory distress syndrome (ARDS). Methods: Multicenter cohort observational study of patients with ARDS at four academic intensive care units. Respiratory drive (P_0.1), diaphragm electrical activity (EAdi), inspiratory effort derived from EAdi (∆Pmus_EAdi) and from occlusion of airway pressure (∆Pocc) (Pmus_ΔPocc), and dynamic transpulmonary driving pressure (ΔP_L,dyn) were measured at the first transition to assisted spontaneous breathing. Results: A total of 4171 breaths were

SUBMITTER: Balzani E 

PROVIDER: S-EPMC11396025 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature