Impact of Methylated Cyclodextrin KLEPTOSE^® CRYSMEB on Inflammatory Responses in Human In Vitro Models.

ABSTRACT: KLEPTOSE^® CRYSMEB methylated cyclodextrin derivative displays less methylated group substitution than randomly methylated cyclodextrin. It has demonstrated an impact on atherosclerosis and neurological diseases, linked in part to cholesterol complexation and immune response, however, its impact on inflammatory cascade pathways is not clear. Thus, the impact of KLEPTOSE^® CRYSMEB on various pharmacological targets was assessed using human umbilical vein endothelial cells under physiological and inflammatory conditions, followed by screening against twelve human primary cell-based systems designed to model complex human tissue and disease biology of the vasculature, skin, lung, and inflammatory tissues using the BioMAP^® Diversity PLUS^® panel. Finall

SUBMITTER: Truffin D 

PROVIDER: S-EPMC11396153 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature