LncRNA LINC00173 inhibits the development of endometrial cancer by interacting with HNRNPC.

ABSTRACT:

Background

Previous research has elaborated on the role of long non-coding RNA LINC00173 in the pathogenesis of various cancers; however, our knowledge of its clinical consequences and mechanisms in endometrial cancer (EC) is limited. Our current work is aimed at investigating the effect of LINC00173 in combination with its upstream gene HNRNPC on EC progression.

Methods

LINC00173 and HNRNPC levels were investigated by qRT-PCR or western blotting in EC tissues. The functional roles of HNRNPC and LINC00173 were assessed using transwell, colony formation and CCK-8 assays. A xenograft was used to verify the phenotype of LINC00173 after its overexpression. The regulatory role between HNRNPC and LINC00173 was investigated using RIP and RNA pull-down analysis.

Results

In EC

SUBMITTER: Zhu Z 

PROVIDER: S-EPMC11396365 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature