Differences in the Renal Accumulation of Radiogallium-Labeled (Glu)₁₄ Peptides Containing Different Optical Isomers of Glutamic Acid.

ABSTRACT: Acidic amino acid peptides have a high affinity for bone. Previously, we demonstrated that radiogallium complex-conjugated oligo-acidic amino acids possess promising properties as bone-seeking radiopharmaceuticals. Here, to elucidate the effect of stereoisomers of Glu in Glu-containing peptides [(Glu)₁₄] on their accumulation in the kidney, the biodistributions of [⁶⁷Ga]Ga-N,N'-bis-[2-hydroxy-5-(carboxyethyl)benzyl]ethylenediamine-N,N'-diacetic acid-conjugated (l-Glu)₁₄ ([⁶⁷Ga]Ga-HBED-CC-(l-Glu)₁₄), [⁶⁷Ga]Ga-HBED-CC-(d-Glu)₁₄, [⁶⁷Ga]Ga-HBED-CC-(dl-Glu)₁₄, and [⁶⁷Ga]Ga-HBED-CC-(d-Glu-l-Glu)₇ were compared. Although the accumulation of these com

SUBMITTER: Ogawa K 

PROVIDER: S-EPMC11396517 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature