Design, Synthesis, and Anticancer and Antibacterial Activities of Quinoline-5-Sulfonamides.

ABSTRACT: A series of new unique acetylene derivatives of 8-hydroxy- and 8-methoxyquinoline- 5-sulfonamide 3a-f and 6a-f were prepared by reactions of 8-hydroxy- and 8-methoxyquinoline- 5-sulfonyl chlorides with acetylene derivatives of amine. A series of new hybrid systems containing quinoline and 1,2,3-triazole systems 7a-h were obtained by reactions of acetylene derivatives of quinoline-5-sulfonamide 6a-d with organic azides. The structures of the obtained compounds were confirmed by ¹H and ¹³C NMR spectroscopy and HR-MS spectrometry. The obtained quinoline derivatives 3a-f and 6a-f and 1,2,3-triazole derivatives 7a-h were tested for their anticancer and antimicrobial activity.

SUBMITTER: Zieba A 

PROVIDER: S-EPMC11396667 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature