Sarcoidosis and Cancer: The Role of the Granulomatous Reaction as a Double-Edged Sword.

ABSTRACT: Background/Objectives: The relationship between sarcoidosis and the occurrence of neoplasia deserves to be investigated, but this relation has been observed in different and heterogeneous populations, leading to conflicting data. To clarify the causal relationship between these two diseases, different risk factors (e.g., smoking), concurrent comorbidities, corticosteroid therapy, and metastasis development-as an expression of cancer aggressiveness-were investigated. Methods: In a retrospective study on 287 sarcoidosis outpatients at the Pneumological Department of the Gemelli Foundation (Rome, Italy) between 2000 and 2024, the diagnosis of cancer was recorded in 36 subjects (12.5%). Results: The reciprocal timeline of the diseases showed three different scenarios: (1)

SUBMITTER: Di Francesco AM 

PROVIDER: S-EPMC11396756 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature