Commonly used genomic arrays may lose information due to imperfect coverage of discovered variants for autism spectrum disorder.

ABSTRACT:

Background

Common genetic variation has been shown to account for a large proportion of ASD heritability. Polygenic scores generated for autism spectrum disorder (ASD-PGS) using the most recent discovery data, however, explain less variance than expected, despite reporting significant associations with ASD and other ASD-related traits. Here, we investigate the extent to which information loss on the target study genome-wide microarray weakens the predictive power of the ASD-PGS.

Methods

We studied genotype data from three cohorts of individuals with high familial liability for ASD: The Early Autism Risk Longitudinal Investigation (EARLI), Markers of Autism Risk in Babies-Learning Early Signs (MARBLES), and the Infant Brain Imaging Study (IBIS), and one population-based sampl

SUBMITTER: Yao M 

PROVIDER: S-EPMC11397030 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature