In Vitro and In Silico Analysis of PTP1B Inhibitors from <i>Cleistocalyx operculatus</i> Leaves and Their Effect on Glucose Uptake.

ABSTRACT: As part of our ongoing research on new anti-diabetic compounds from ethnopharmacologically consumed plants, two previously undescribed lupane-type triterpenoids (1 and 2) with dicarboxylic groups, an undescribed nor-taraxastane-type triterpenoid (3), and 14 known compounds (4-17) were isolated from the leaves of Cleistocalyx operculatus. Extensive spectroscopic analysis (IR, HRESIMS, 1D, and 2D NMR) was used for structure elucidation, while the known compounds were compared to reference data reported in the scientific literature. All the isolates (1-17) were evaluated for their inhibitory effects on the protein tyrosine phosphatase 1B (PTP1B) enzyme. Compounds 6, 9, and 17 showed strong PTP1B inhibitory activities

SUBMITTER: Ponce-Zea JE 

PROVIDER: S-EPMC11397035 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature