Influence of Solvent Relative Permittivity in Swab Spray Mass Spectrometry.

ABSTRACT: The influence of solvent properties on ion generation by swab spray ionization was investigated. The ability of a variety of solvents of different relative permittivity, surface tension, and viscosity to form a stable and reproducible electrospray was examined. It is demonstrated that in swab spray ionization, a crucial balance between solvent composition, applied potential, and the solvent flow fed to the swab head must be maintained. The solvent composition was found to significantly affect the shape of the Taylor cone and the emerging cone jet, which eventually have an impact on the resulting ion yield. The results indicate that the relative permittivity of solvents measured under standard conditions is the main factor governing jet shaping, and consequently, the ionization efficacy. Sh

SUBMITTER: Muggli TM 

PROVIDER: S-EPMC11397147 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature