PGRMC1 contributes to doxorubicin-induced chemoresistance in MES-SA uterine sarcoma.

ABSTRACT: Chemotherapy is one of the major categories of medical oncology and a primary tumor treatment; however, the effectiveness of chemotherapy is restricted by drug resistance. Overcoming resistance to chemotherapy and investigating molecular targeted therapies are challenges currently faced during resistance management. Progesterone receptor membrane component 1 (PGRMC1) is an adapter protein mediating cholesterol synthesis, steroid signaling, and cytochrome p450 activation. Attention has recently focused on the role of PGRMC1 in cell survival, anti-apoptosis, and damage response. In the present study, we used knockdown and overexpression approaches in the following set of uterine sarcoma models to further evaluate the role of PGRMC1 in drug resistance: the doxorubicin-sensitive MES-SA cells a

SUBMITTER: Lin ST 

PROVIDER: S-EPMC11397629 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature