Organoids: fundamentals, present and future.

ABSTRACT: Organoids are tiny structures, mainly generated from induced pluripotent stem cells, which are cultured in the laboratory while retaining their innate or acquired characteristics. They have the potential to reproduce biological development processes, model pathological processes that will enable the discovery of new drugs and promote regenerative medicine. However, these processes require constant improvement because variations may have occurred in the constitution of the organs. Therefore, this article aims to review updated information on organoids and their basic and recent experimental processes, starting with gastrulation, in an attempt to mimic, as much as possible, the formation of the three layers: ectoderm, mesoderm and endoderm; as well as the information regarding the factors in

SUBMITTER: Amiel-Perez J 

PROVIDER: S-EPMC11397781 | biostudies-literature | 2022 Apr-Jun

REPOSITORIES: biostudies-literature