Brain-wide circuitry underlying altered auditory habituation in zebrafish models of autism.

ABSTRACT: Auditory processing is widely understood to occur differently in autism, though the patterns of brain activity underlying these differences are not well understood. The diversity of autism also means brain-wide networks may change in various ways to produce similar behavioral outputs. We used larval zebrafish to investigate auditory habituation in four genetic lines relevant to autism: fmr1, mecp2, scn1lab and cntnap2. In free-swimming behavioral tests, we found each line had a unique profile of auditory hypersensitivity and/or delayed habituation. Combining the optical transparency of larval zebrafish with genetically encoded calcium indicators and light-sheet microscopy, we then observed brain-wide activity at cellular resolution during auditory habituation. A

SUBMITTER: Wilde M 

PROVIDER: S-EPMC11398315 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature