The Hox Gene, <i>abdominal-A</i>, controls the size and timely mitotic entry of neural stem cells during CNS patterning in <i>Drosophila</i>.

ABSTRACT: Cell size is a critical determinant of its function and physiology. In this study, we investigated the regulation of stem cell size during Drosophila central nervous system (CNS) development and its association with cell fate. We note that neural stem cells (NSCs) in different regions of ventral nerve cord increase their size at different rates. The, thoracic NSCs grow at a faster rate compared to those in the abdominal region. We show that in addition to its role in apoptosis and nervous system remodeling, abdA also plays an instructive role in regulating the rate of NSC size increase and its timely entry into mitosis. Weak expression of abdA in larval abdominal NSCs was sufficient to retard the rate of their size increase and delay their mitotic entry compared to thoracic N

SUBMITTER: Das P 

PROVIDER: S-EPMC11398374 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature