Sex-specific differences in brain activity dynamics of youth with a family history of substance use disorder.

ABSTRACT: An individual's risk of substance use disorder (SUD) is shaped by a complex interplay of potent biosocial factors. Current neurodevelopmental models posit vulnerability to SUD in youth is due to an overreactive reward system and reduced inhibitory control. Having a family history of SUD is a particularly strong risk factor, yet few studies have explored its impact on brain function and structure prior to substance exposure. Herein, we utilized a network control theory approach to quantify sex-specific differences in brain activity dynamics in youth with and without a family history of SUD, drawn from a large cohort of substance-naïve youth from the Adolescent Brain Cognitive Development Study. We summarize brain dynamics by calculating transition energy, which probes the ease with which a

SUBMITTER: Schilling L 

PROVIDER: S-EPMC11398379 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature