Analysis of C-reactive protein omics-measures associates methylation risk score with sleep health and related health outcomes.

ABSTRACT:

Introduction

DNA methylation (DNAm) predictors of high sensitivity C-reactive protein (CRP) offer a stable and accurate means of assessing chronic inflammation, bypassing the CRP protein fluctuations secondary to acute illness. Poor sleep health is associated with elevated inflammation (including elevated blood CRP levels) which may explain associations of sleep insufficiency with metabolic, cardiovascular and neurological diseases. Our study aims to characterize the relationships among sleep health phenotypes and CRP markers -blood, genetic, and epigenetic indicators-within the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).

Methods

In HCHS/SOL, methylation risk scores (MRS)-CRP and polygenetic risk score (PRS)-CRP were constructed separately as weighted sums o

SUBMITTER: Wang Z 

PROVIDER: S-EPMC11398435 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature