Gut Microbiome Compositional and Functional Features Associate with Alzheimer's Disease Pathology.

ABSTRACT:

Background

The gut microbiome is a potentially modifiable factor in Alzheimer's disease (AD); however, understanding of its composition and function regarding AD pathology is limited.

Methods

Shallow-shotgun metagenomic data was used to analyze fecal microbiome from participants enrolled in the Wisconsin Microbiome in Alzheimer's Risk Study, leveraging clinical data and cerebrospinal fluid (CSF) biomarkers. Differential abundance and ordinary least squares regression analyses were performed to find differentially abundant gut microbiome features and their associations with CSF biomarkers of AD and related pathologies.

Results

Gut microbiome composition and function differed between people with AD and cognitively unimpaired individuals. The compositional difference was

SUBMITTER: Kang JW 

PROVIDER: S-EPMC11398448 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature