Metapipeline-DNA: A Comprehensive Germline & Somatic Genomics Nextflow Pipeline.

ABSTRACT:

Summary

The price, quality and throughout of DNA sequencing continue to improve. Algorithmic innovations have allowed inference of a growing range of features from DNA sequencing data, quantifying nuclear, mitochondrial and evolutionary aspects of both germline and somatic genomes. To automate analyses of the full range of genomic characteristics, we created an extensible Nextflow meta-pipeline called metapipeline-DNA. Metapipeline-DNA analyzes targeted and whole-genome sequencing data from raw reads through pre-processing, feature detection by multiple algorithms, quality-control and data- visualization. Each step can be run independently and is supported robust software engineering including automated failure-recovery, robust testing and consistent verifications of inputs, output

SUBMITTER: Patel Y 

PROVIDER: S-EPMC11398472 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature