An RNA binding regulatory cascade controls the switch from proliferation to differentiation in the <i>Drosophila</i> male germ cell lineage.

ABSTRACT: The switch from precursor cell proliferation to onset of differentiation in adult stem cell lineages must be carefully regulated to produce sufficient progeny to maintain and repair tissues, yet prevent overproliferation that may enable oncogenesis. In the Drosophila male germ cell lineage, spermatogonia produced by germ line stem cells undergo a limited number of transit amplifying mitotic divisions before switching to the spermatocyte program that sets up meiosis and eventual spermatid differentiation. The number of transit amplifying divisions is set by accumulation of the bag-of-marbles (Bam) protein to a critical threshold. In bam mutants, spermatogonia proliferate through several extra rounds of mitosis then die without becoming spermatocytes. Here we show that a

SUBMITTER: Harris DE 

PROVIDER: S-EPMC11398533 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature