Origin of yield stress and mechanical plasticity in model biological tissues.

ABSTRACT: During development and under normal physiological conditions, biological tissues are continuously subjected to substantial mechanical stresses. In response to large deformations cells in a tissue must undergo multicellular rearrangements in order to maintain integrity and robustness. However, how these events are connected in time and space remains unknown. Here, using computational and theoretical modeling, we studied the mechanical plasticity of epithelial monolayers under large deformations. Our results demonstrate that the jamming-unjamming (solid-fluid) transition in tissues can vary significantly depending on the degree of deformation, implying that tissues are highly unconventional materials. Using analytical modeling, we elucidate the origins of this behavior. We also demonstrate h

SUBMITTER: Nguyen AQ 

PROVIDER: S-EPMC11398538 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature