A novel antigen biomarker for detection of high-level of Loa loa microfilaremia.

ABSTRACT:

Background

Loiasis is a disease caused by the nematode Loa loa. Serious adverse events sometimes occur in people with heavy L. loa microfilaremia after ivermectin treatment. In regions of Central Africa where loiasis is endemic, this significantly impedes global elimination programs for lymphatic filariasis and onchocerciasis that use mass distribution of ivermectin. Improved diagnostic tests to identify individuals at increased risk of serious adverse events could facilitate efforts to eliminate lymphatic filariasis and onchocerciasis in this region.

Methods and findings

We previously identified the L. loa protein Ll-Bhp-1 in loiasis patient sera. Here, we further characterize Ll-Bhp-1 and report development of an antigen capture ELISA to detect this antigen. This assay det

SUBMITTER: Greene SE 

PROVIDER: S-EPMC11398663 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature