Applying Super-Resolution and Tomography Concepts to Identify Receptive Field Subunits in the Retina.

ABSTRACT: Spatially nonlinear stimulus integration by retinal ganglion cells lies at the heart of various computations performed by the retina. It arises from the nonlinear transmission of signals that ganglion cells receive from bipolar cells, which thereby constitute functional subunits within a ganglion cell's receptive field. Inferring these subunits from recorded ganglion cell activity promises a new avenue for studying the functional architecture of the retina. This calls for efficient methods, which leave sufficient experimental time to leverage the acquired knowledge for further investigating identified subunits. Here, we combine concepts from super-resolution microscopy and computed tomography and introduce super-resolved tomographic reconstruction (STR) as a technique to efficiently stimul

SUBMITTER: Kruppel S 

PROVIDER: S-EPMC11398665 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature