The association between genetically predicted systemic inflammatory regulators and endometriosis: A bidirectional Mendelian randomization study.

ABSTRACT: Elevated levels of various cellular inflammatory markers have been observed in patients with endometriosis (EMs). However, a causal relationship between these markers and EMS has not been firmly established. This study aimed to assess the causality between cellular inflammatory markers and the onset of EMS using a bidirectional Mendelian randomization approach. Genetic associations for EMs were derived from the largest and most recent genome-wide association study (GWAS) involving 1937 EMS cases and 245,603 controls of European ancestry. Single nucleotide polymorphisms associated with 41 cellular cytokines and other systemic inflammatory regulators were identified from 8293 Finnish participants. Estimates were obtained using inverse-variance weighted, with sensitivity analyses conducted us

SUBMITTER: Liu Y 

PROVIDER: S-EPMC11398771 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature