Identification and validation of basement membrane-related genes predicting prognosis and immune infiltration associated with bladder cancer.

ABSTRACT: Bladder cancer (BC) is fatal during muscle invasion and treatment progress is limited. In this study, we aimed to construct and validate basement membrane (BM)-associated gene prognosis to predict BC progression and tumor immune infiltration correlation. We choreographed BM-related genes in the Cancer Genome Atlas (TCGA) database using COX regression and least absolute shrinkage and selection operator (LASSO) analysis, and the predictive value of BM-related genes was further validated by the GSE32548, GSE129845, and immunohistochemistry staining. All analyses were performed with R-version 4.2.2, and its appropriate packages. Three genes were identified to construct a gene signature to predictive of BC prognosis. We divided the TCGA database into 2 groups, and patients in the high-risk grou

SUBMITTER: Lai F 

PROVIDER: S-EPMC11398827 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature